MODE OF INHIBITION OF RESPIRATOR SYNCYTIAL VIRUS BY A PLANT FLAVONOID, SP-303

被引：24

作者：

BARNARD, DL ^{[1
]}

HUFFMAN, JH ^{[1
]}

MEYERSON, LR ^{[1
]}

SIDWELL, RW ^{[1
]}

机构：

[1] SHAMAN PHARMACEUT INC, SAN CARLOS, CA USA

来源：

CHEMOTHERAPY | 1993年 / 39卷 / 03期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; ANTIVIRAL; SP-303; FLAVONOID; MECHANISM; PENETRATION; PLANT; NATURAL PRODUCT; EUPHORBIACEAE;

D O I：

10.1159/000239128

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A natural-product polyphenolic polymer of molecular weight 2,100 daltons designated SP-303, was found to have antiviral activity against respiratory syncytial virus (RSV) in the 2-10 muM range in plaque reduction assays and cytopathic-effect-inhibition assays. The material was also virucidal. The 50% effective concentration (EC50) for virucidal activity was 28 muM. Experiments were done to determine the mode(s) of RSV inhibition by SP-303. Interferon was not induced. SP-303 did not inhibit attachment at antiviral concentrations. However, the EC50 for inhibition of virus penetration by SP-303 was 0.48 +/- 0.19 muM. These data suggest that abolition of RSV penetration into host cells is one mechanism whereby SP-303 inhibits RSV replication.

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页码：212 / 217

页数：6

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