Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions

被引：47

作者：

Fennell, Vernard S. ^{[1
]}

Kalani, M. Yashar S. ^{[1
]}

Atwal, Gursant ^{[1
]}

Martirosyan, Nikolay L. ^{[1
]}

Spetzler, Robert F. ^{[1
]}

机构：

[1] St Josephs Hosp, Barrow Neurol Inst, Dept Neurosurg, Phoenix, AZ 85013 USA

来源：

FRONTIERS IN SURGERY | 2016年 / 3卷

关键词：

biology; inflammation; intracranial aneurysm;

D O I：

10.3389/fsurg.2016.00043

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.

引用

页数：8

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