MECHANISM OF TIMOLOL IN LOWERING INTRA-OCULAR PRESSURE - IN NORMAL EYE

被引：307

作者：

COAKES, RL ^{[1
]}

BRUBAKER, RF ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT OPHTHALMOL,ROCHESTER,MN 55901

来源：

ARCHIVES OF OPHTHALMOLOGY | 1978年 / 96卷 / 11期

关键词：

D O I：

10.1001/archopht.1978.03910060433007

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A single-drop, double-masked, randomized, placebo-controlled study of the mechanism of the ocular-pressure lowering property of timolol maleate, a β-adrenergic blocker, was carried out in 23 normal subjects, using fluorophotometry. Timolol suppressed aqueous formation in all subjects. The range of suppression was 13% to 48%, with a mean ± SD of 34% ± 9%. The drug had no effect on anterior chamber volume or endothelial permeability to fluorescein and, apparently, had no effect on outflow resistance. No differences were observed between its effect on men and women or between eyes with light and dark irides. © 1978, American Medical Association. All rights reserved.

引用

页码：2045 / 2048

页数：4