Protein Tyrosine Kinases: Challenges in the Development of Drugs Aimed at Cancer Therapy

被引：9
作者：
Avila, Carolina M. [1 ]
Romeiro, Nelilma C. [1 ,2 ]
机构：
[1] Univ Fed Rio de Janeiro, Fac Farm, Lab Avaliacao & Sintese Subst Bioativas, LASSBio, Caixa Postal 68023, BR-21941902 Rio De Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Nucleo Pesquisas Ecol & Desenvolvimento Social Ma, NUPEM, BR-27901000 Macae, RJ, Brazil
来源：
REVISTA VIRTUAL DE QUIMICA | 2010年 / 2卷 / 01期
关键词：
Protein tyrosine kinases; cancer; anticancer;
D O I：
10.5935/1984-6835.20100007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper describes recent information on protein tyrosine kinases and their importance as molecular targets in cancer therapy, as well as the challenges involved in selective binding of drugs while overcoming resistance. Special attention is given to X-ray diffraction studies of enzyme-inhibitor co-crystals, which have demonstrated new binding modes of the second generation of anticancer drugs, tyrosine kinase inhibitors.
引用
收藏
页码：59 / 82
页数：24
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