NITRIC-OXIDE REGULATES MITOCHONDRIAL RESPIRATION AND CELL FUNCTIONS BY INHIBITING CYTOCHROME-OXIDASE

被引：481
作者：
BROWN, GC
机构：
[1] Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, Tennis Court Road
来源：
FEBS LETTERS | 1995年 / 369卷 / 2-3期
关键词：
NITRIC OXIDE; CYTOCHROME C OXIDASE; MITOCHONDRIA; OXYGEN SENSOR; MUSCLE RELAXATION; CYTOKINES;
D O I：
10.1016/0014-5793(95)00763-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.
引用
收藏
页码：136 / 139
页数：4
相关论文
共 40 条
[1]   MECHANISMS OF IMMUNE-MEDIATED MYOCYTE INJURY [J].
BARRY, WH .
CIRCULATION, 1994, 89 (05) :2421-2432
[2]  
BOLANOS JP, 1994, J NEUROCHEM, V63, P910
[3]   NITRIC-OXIDE PRODUCED BY ACTIVATED ASTROCYTES RAPIDLY AND REVERSIBLY INHIBITS CELLULAR RESPIRATION [J].
BROWN, GC ;
BOLANOS, JP ;
HEALES, SJR ;
CLARK, JB .
NEUROSCIENCE LETTERS, 1995, 193 (03) :201-204
[4]  
BROWN GC, 1992, BIOCHEM J, V284, P1
[5]   NANOMOLAR CONCENTRATIONS OF NITRIC-OXIDE REVERSIBLY INHIBIT SYNAPTOSOMAL RESPIRATION BY COMPETING WITH OXYGEN AT CYTOCHROME-OXIDASE [J].
BROWN, GC ;
COOPER, CE .
FEBS LETTERS, 1994, 356 (2-3) :295-298
[6]   REACTIONS OF NITRIC-OXIDE WITH CYTOCHROME-C OXIDASE [J].
BRUDVIG, GW ;
STEVENS, TH ;
CHAN, SI .
BIOCHEMISTRY, 1980, 19 (23) :5275-5285
[7]   NITRIC-OXIDE FORMED BY NITRITE REDUCTASE OF PARACOCCUS-DENITRIFICANS IS SUFFICIENTLY STABLE TO INHIBIT CYTOCHROME-OXIDASE ACTIVITY AND IS REDUCED BY ITS REDUCTASE UNDER AEROBIC CONDITIONS [J].
CARR, GJ ;
FERGUSON, SJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1017 (01) :57-62
[8]   REVERSIBLE INHIBITION OF CYTOCHROME-C-OXIDASE, THE TERMINAL ENZYME OF THE MITOCHONDRIAL RESPIRATORY-CHAIN, BY NITRIC-OXIDE - IMPLICATIONS FOR NEURODEGENERATIVE DISEASES [J].
CLEETER, MWJ ;
COOPER, JM ;
DARLEYUSMAR, VM ;
MONCADA, S ;
SCHAPIRA, AHV .
FEBS LETTERS, 1994, 345 (01) :50-54
[9]  
COOPER CE, 1995, IN PRESS BIOCH BIOPH
[10]   INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR SYNERGIZE TO INDUCE NITRIC-OXIDE PRODUCTION AND INHIBIT MITOCHONDRIAL RESPIRATION IN VASCULAR SMOOTH-MUSCLE CELLS [J].
GENG, Y ;
HANSSON, GK ;
HOLME, E .
CIRCULATION RESEARCH, 1992, 71 (05) :1268-1276
1234