ANAPHYLACTOID AND ANAPHYLACTIC REACTIONS - HAZARDS OF BETA-BLOCKERS

被引：66
作者：
LANG, DM
机构：
[1] Department of Medicine, Division of Allergy and Immunology, Hahnemann University, Philadelphia, Philadelphia, 19102-1192, Mail Stop 107, Broad and Vine Streets
来源：
DRUG SAFETY | 1995年 / 12卷 / 05期
关键词：
D O I：
10.2165/00002018-199512050-00002
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving beta-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to beta-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired alpha-adrenergic and vogotonic effects. Risk reduction efforts should be considered for patients receiving beta-blockers who are prone to experience anaphylaxis.
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页码：299 / 304
页数：6
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