IGA NEPHROPATHY AND IDIOPATHIC THROMBOCYTOPENIC PURPURA WITH SPLENECTOMY - A CASE-REPORT

被引：9
作者：
MORINO, M
INAMI, K
SHIBUYA, A
SASAKI, N
机构：
[1] Department of Paediatrics, Saitama Medical School, Saitama, 350-04
来源：
PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 03期
关键词：
SPLENECTOMY; IGA NEPHROPATHY; IMMUNE COMPLEXES; IDIOPATHIC THROMBOCYTOPENIC PURPURA; RETICULOENDOTHELIAL SYSTEM;
D O I：
10.1007/BF00866358
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
引用
收藏
页码：345 / 346
页数：2
相关论文
共 10 条
  • [1] Watanabe K., Watanabe H., Kida S., Funabasi Y., Ookubo Y., Et al., Detection of immune complexes by monoclonal anti-C1q and C3d ELISA systems, Jpn J Clin Immunol, 12, pp. 369-378, (1989)
  • [2] van den Wall Bake A.W.L., Daha, Haaijman J.J., Radl J., van der Ark A., van Es L.A., Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy, Kidney International, 35, pp. 1400-1404, (1989)
  • [3] van Es L.A., Pathogenesis of IgA nephropathy, Kidney Int, 41, pp. 1720-1729, (1992)
  • [4] Smith S.M., Tokuda S., Tsukamoto H., Mucosal immune dysfunction associated with alcoholic IgA nephropathy, Clin Immunol Immunopathol, 64, pp. 205-209, (1992)
  • [5] Drew P.A., Kiroff G.K., Ferrante A., Cohen R.C., Alterations in immunoglobulin sysnthesis by peripheral blood mononuclear cells from splenectomized patients with and without splenic regrowth, J Immunol, 132, pp. 191-196, (1984)
  • [6] Emancipator S.N., Lamm M.E., Biology of disease. IgA nephropathy: pathogenesis of the most common form of glomerulonephritis, Lab Invest, 60, pp. 168-183, (1989)
  • [7] Haakenstad A.O., Mannik M., The disappearance kinetics of soluble immune complexes prepared with reduced and alkylated antibodies and with intact antibodies in mice, Lab Invest, 35, pp. 283-292, (1976)
  • [8] Roccatello D., Piccitto G., Coppo R., Piccoli G., Molino A., Cacace G., Amore A., Quattrocchio G., Ropolo R., Mossso R., Amoroso A., Sena L.M., The fate of aggregated immunoglobulin A injected in IgA nephropathy patients and healthy controls, Am J Kidney Dis, 18, pp. 20-25, (1991)
  • [9] Lobatto S., Daha, Voetman A.A., Evers-schouten J.H., van Es A.A., Pauels E.K.J., van Es L.A., Clearance of soluble aggregates of human immunoglobulin G in healthy volunteers and chimpanzees, Clin Exp Immunol, 68, pp. 133-141, (1987)
  • [10] Emancipator S.N., Lamm M.E., IgA nephropathy: over-production or decreased clearance of immune complexes?, Lab Invest, 61, pp. 365-367, (1989)
1