REGIOSELECTIVE SYNTHESIS AND ANTIVIRAL ACTIVITY OF PURINE NUCLEOSIDE ANALOGS WITH ACYCLIC SUBSTITUENTS AT N7

被引：33

作者：

JAHNE, G ^{[1
]}

KROHA, H ^{[1
]}

MULLER, A ^{[1
]}

HELSBERG, M ^{[1
]}

WINKLER, I ^{[1
]}

GROSS, G ^{[1
]}

SCHOLL, T ^{[1
]}

机构：

[1] HOECHST AG, RADIOCHEM LAB, W-6230 FRANKFURT, GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1994年 / 33卷 / 05期

关键词：

D O I：

10.1002/anie.199405621

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of antiviral compounds is heralded by purine derivative 1, which in vitro tests showed to have good antiherpes action. This compound proves that, like the natural purine nucleosides with a cyclic residue at N9, derivatives with an acyclic substituent at N7 can also be active. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

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页码：562 / 563

页数：2

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