SYNTHESIS OF A REVERSE ESTER ANALOG OF 1,2-SN-DIGLYCERIDES FROM (S)-1,2-DI-O-ISOPROPYLIDENEGLYCEROL - EFFICIENT, STEREOSPECIFIC NUCLEOPHILIC DISPLACEMENT VIA A TRIFLATE AT GLYCEROL C-2

被引：12

作者：

GOLDING, BT ^{[1
]}

GRIFFIN, AL ^{[1
]}

ROBINSON, DH ^{[1
]}

机构：

[1] FISONS PLC,DIV PHARMACEUT,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 40期

关键词：

PHOSPHOLIPASE A(2); INHIBITOR; GLYCERIDE; TRIFLATE; TRESYLATE; DISPLACEMENT;

D O I：

10.1016/0040-4039(93)85070-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An optically pure glyceride analogue in which the 2-0-ester grouping has been reversed was efficiently synthesised from (S)-di-O-isopropylideneglycerol by a sequence that featured an S(N)2 displacement by the anion of diethyl malonate on a protected glycerol 2-0-triflate.

引用

页码：6459 / 6462

页数：4

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