ANALYSIS OF DIABETIC CATARACTOGENESIS USING CHEMICAL-SHIFT NUCLEAR-MAGNETIC-RESONANCE MICROSCOPY

被引：8
作者：
CHENG, HM
AGUAYO, JB
MOORE, GJ
MATTINGLY, M
机构：
[1] MASSACHUSETTS EYE & EAR HOSP,BOSTON,MA 02114
[2] BRUKER MED INSTRUMENTS,BILLERICA,MA 01821
来源：
MAGNETIC RESONANCE IN MEDICINE | 1991年 / 17卷 / 01期
关键词：
D O I：
10.1002/mrm.1910170111
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We here report the analysis of single rabbit lenses under high‐glucose stress using four‐dimensional 13C nuclear magnetic resonance (NMR) spectroscopy (three spatial and one chemical‐shift). We have produced spatial maps of lenticular metabolites (glucose, sorbitol, and lactate) with submillimeter in‐plane resolution. The production of sorbitol and its inhibition are also presented. This is the first study to report regional tissue metabolism. We expect further improvements in spatial resolution and acquisition times that will enable localized kinetic studies in intact tissues. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
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页码：62 / 68
页数：7
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