Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam

被引：13
作者：
Schimmenti, A. [1 ]
Brunetti, E. [1 ,2 ]
Seminari, E. [2 ]
Mariani, B. [3 ]
Cambieri, P. [3 ]
Orsolini, P. [2 ,4 ]
机构：
[1] Univ Pavia, Unita Malattie Infett & Trop Epatol, Dipartimento Sci Clinicochirurg & Diagnost & Pedi, Pavia, Italy
[2] Fdn IRCCS Policlin San Matteo, Unita Malattie Infett & Trop, Pavia, Italy
[3] Fdn IRCCS Policlin San Matteo, Microbiol & Virol, Pavia, Italy
[4] Univ Pavia, Dipartimento Med Interna & Terapia Med, Pavia, Italy
来源：
CASE REPORTS IN INFECTIOUS DISEASES | 2018年 / 2018卷
关键词：
D O I：
10.1155/2018/1854805
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.
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