IL-15, A NOVEL T-CELL GROWTH-FACTOR THAT SHARES ACTIVITIES AND RECEPTOR COMPONENTS WITH IL-2

被引:189
作者
GIRI, JG
ANDERSON, DM
KUMAKI, S
PARK, LS
GRABSTEIN, KH
COSMAN, D
机构
关键词
INTERLEUKIN; 15; CLONING; RECEPTORS; X-SCID;
D O I
10.1002/jlb.57.5.763
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Interleukin 15 is a newly discovered cytokine that shares biological activities with IL-2 and, like IL-2, is a member of the four-helix bundle cytokine family, We have shown that IL-15 shares components of the receptor for IL-2: the alpha chain of the IL-2R is not required, but both the beta and gamma chains are needed for IL-15 mediated bioactivities, A defect in IL-15 signaling may therefore contribute to the phenotype of X-linked severe combined immunodeficiency in humans, resulting from mutations in the common gamma chain, Differential ability of cells to bind and respond to IL-2 and IL-15 suggested the existence of an additional IL-15 specific receptor component, We identified an IL-15 specific binding protein (IL-15R alpha) on a murine T cell and isolated the corresponding cDNA, The IL-15R alpha is not a member of the hematopoietin receptor superfamily, but is structurally related to the a chain of the IL-2R. Differences in the expression pattern of IL-15 and its receptor compared to the IL-2 system suggest unique in vivo roles for IL-15.
引用
收藏
页码:763 / 766
页数:4
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