THE CENTRAL EFFECT OF METHIONINE-ENKEPHALIN ON NK CELL-ACTIVITY

被引:27
作者
HSUEH, CM
HIRAMOTO, RN
GHANTA, VK
机构
[1] UNIV ALABAMA, DEPT MICROBIOL, UNIV STN, BIRMINGHAM, AL 35294 USA
[2] UNIV ALABAMA, DEPT BIOL, BIRMINGHAM, AL 35294 USA
关键词
METHIONINE-ENKEPHALIN; OPIOID; OPIOID ANTAGONIST; NATURAL KILLER CELL ACTIVITY;
D O I
10.1016/0006-8993(92)90241-Z
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The central effect of opioid peptide on natural killer (NK) cell activity in BALB/c mice was investigated. Injection of methionine-enkephalin (Met-Enk), 0.02-mu-g/mouse or 1-mu-g/kg, directly into the cisterna magna (CM) of the brain, resulted in a significant enhancement of NK cell activity. This enhancement was blocked by opiate antagonists, naltrexone and quaternary naltrexone. The same dose of Met-Enk had no effect on NK cell activity when given to the mouse intraperitoneally or intraveneously. Moreover, des-tyrosine-methionine-enkephalin injected into the CM at 1-mu-g/kg, had no effect on NK cell activity. The results indicate that activation of an opioid-mediated pathway in the central nervous system is capable of activating the pathways that stimulate the NK cell response in the periphery.
引用
收藏
页码:142 / 148
页数:7
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