EFFECT OF PHYLLANTHUS-AMARUS ON DUCK HEPATITIS-B VIRUS-REPLICATION INVIVO

被引：23
作者：
NIU, JZ
WANG, YY
QIAO, M
GOWANS, E
EDWARDS, P
THYAGARAJAN, SP
GUST, I
LOCARNINI, S
机构：
[1] FAIRFIELD HOSP,MACFARLANE BURNET CTR MED RES,HEPATITIS RES UNIT,YARRA BEND RD,FAIRFIELD,VIC 3078,AUSTRALIA
[2] HYG & ANTIEPIDEM STN,BAODING,PEOPLES R CHINA
[3] INST MED & VET SCI,DEPT VIROL,HEPATITIS RES UNIT,ADELAIDE,SA 5000,AUSTRALIA
[4] DR ALM POST GRAD INST BASIC MED SCI,DEPT MICROBIOL,MADRAS,INDIA
来源：
JOURNAL OF MEDICAL VIROLOGY | 1990年 / 32卷 / 04期
关键词：
PHYLLANTHUS-AMARUS; DUCK HEPATITIS-B VIRUS; ANTIVIRAL THERAPY; TRADITIONAL REMEDIES; ANIMAL MODELS;
D O I：
10.1002/jmv.1890320404
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal-treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.
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页码：212 / 218
页数：7
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