Hepatic Failure Due to Cholestatic Hepatitis C in an Immunosuppressed Patient Treated With Elbasvir and Grazeprevir

被引：0

作者：

Nassar, Amin H. ^{[1
]}

Abdul-Jawad, Baraa M. ^{[2
]}

Barnes, David S. ^{[2
]}

机构：

[1] Brigham & Womens Hosp, Dept Pulm Med & Crit Care, 45 Francis St, Boston, MA 02115 USA

[2] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44106 USA

来源：

ACG CASE REPORTS JOURNAL | 2018年 / 5卷

关键词：

D O I：

10.14309/crj.2018.6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis C-induced cholestatic hepatitis is a well-known fatal complication of postorthotropic liver transplantation and prolonged immunosuppression. Recent studies on direct-acting antiviral agents have shown promising results in terms of morbidity and mortality of this condition in postorthotropic liver, heart, and renal transplant patients. However, hepatitis C-induced cholestatic hepatitis remains a highly fatal condition in non-transplant patients. We report the first-ever use of the oral direct-acting antiviral combination, elbasvir and grazeprevir, in the treatment of a non-liver transplant patient with cholestatic hepatitis.

引用

页数：3

共 16 条

[1] Treatment of Hepatitis C Virus Infection in Kidney Transplant Recipients: Case Report [J].

Caeiro, F. ;

Baptista, V. ;

Rodrigues, N. ;

Carvalho, D. ;

Aires, I. ;

Remedio, F. ;

Nolasco, F. .

TRANSPLANTATION PROCEEDINGS, 2011, 43 (01) :259-262

[2] Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease [J].

Charlton, Michael ;

Everson, Gregory T. ;

Flamm, Steven L. ;

Kumar, Princy ;

Landis, Charles ;

Brown, Robert S., Jr. ;

Fried, Michael W. ;

Terrault, Norah A. ;

O'Leary, Jacqueline G. ;

Vargas, Hugo E. ;

Kuo, Alexander ;

Schiff, Eugene ;

Sulkowski, Mark S. ;

Gilroy, Richard ;

Watt, Kymberly D. ;

Brown, Kimberly ;

Kwo, Paul ;

Pungpapong, Surakit ;

Korenblat, Kevin M. ;

Muir, Andrew J. ;

Teperman, Lewis ;

Fontana, Robert J. ;

Denning, Jill ;

Arterburn, Sarah ;

Dvory-Sobol, Hadas ;

Brandt-Sarif, Theo ;

Pang, Phillip S. ;

McHutchison, John G. ;

Reddy, K. Rajender ;

Afdhal, Nezam .

GASTROENTEROLOGY, 2015, 149 (03) :649-659

[3] HEPATIC HISTOLOGICAL-FINDINGS AFTER TRANSPLANTATION FOR CHRONIC HEPATITIS-B VIRUS-INFECTION, INCLUDING A UNIQUE PATTERN OF FIBROSING CHOLESTATIC HEPATITIS [J].

DAVIES, SE ;

PORTMANN, BC ;

OGRADY, JG ;

ALDIS, PM ;

CHAGGAR, K ;

ALEXANDER, GJM ;

WILLIAMS, R .

HEPATOLOGY, 1991, 13 (01) :150-157

[4] Survival of liver transplant patients coinfected with HIV and HCV is adversely impacted by recurrent hepatitis C [J].

de Vera, M. E. ;

Dvorchik, I. ;

Tom, K. ;

Eghtesad, B. ;

Thai, N. ;

Shakil, O. ;

Marcos, A. ;

Demetris, A. ;

Jain, A. ;

Fung, J. J. ;

Ragni, M. V. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (12) :2983-2993

[5] Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection [J].

Delladetsima, JK ;

Boletis, JN ;

Makris, F ;

Psichogiou, M ;

Kostakis, A ;

Hatzakis, A .

LIVER TRANSPLANTATION AND SURGERY, 1999, 5 (04) :294-300

[6]

DEMETRIS AJ, 1990, AM J PATHOL, V137, P667

[7] HIGH-LEVEL EXPRESSION OF HEPATITIS-B VIRAL-ANTIGENS IN FIBROSING CHOLESTATIC HEPATITIS [J].

LAU, JYN ;

BAIN, VG ;

DAVIES, SE ;

OGRADY, JG ;

ALBERTI, A ;

ALEXANDER, GJM ;

WILLIAMS, R .

GASTROENTEROLOGY, 1992, 102 (03) :956-962

[8] Treatment of de novo hepatitis C virus-related fibrosing cholestatic hepatitis after orthotopic heart transplantation by ledipasvir and sofosbuvir [J].

Liu, Chen-Hua ;

Chen, Yih-Sharng ;

Wang, Sheoi-Shen ;

Kao, Jia-Horng .

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2017, 116 (05) :407-409

[9]

Morii KYT, 2012, J GASTROEN HEPATOL, V1, P165

[10] Post-Liver Transplant Cholestatic Hepatitis C: A Systematic Review of Clinical and Pathological Findings and Application of Consensus Criteria [J].

Narang, Torun K. ;

Ahrens, Will ;

Russo, Mark W. .

LIVER TRANSPLANTATION, 2010, 16 (11) :1228-1235

← 1 2 →