A DIRECT SYNTHESIS OF A BIFUNCTIONAL CHELATING AGENT FOR RADIOLABELING PROTEINS

被引：21
作者：
BRECHBIEL, MW
MCMURRY, TJ
GANSOW, OA
机构：
[1] Chemistry Section, Radiation Oncology Branch, National Institute of Health, Bethesda
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 23期
关键词：
D O I：
10.1016/S0040-4039(00)79202-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient synthesis of a bifunctional derivative of the ligand NOTA is described. The synthesis offers advantages over current literature methods for making similar molecules by starting with the easily prepared ortho-amide of 1,4,7-triazacyclononane which can be sequentially alkylated to provide a bifunctional NOTA derivative in 9% yield overall. The replacement of preparative HPLC with simple ion-exchange chromatography provides analytically pure ligand suitable for clinical applications.
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收藏
页码：3691 / 3694
页数：4
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