GENETIC-MAPPING OF X-LINKED OCULAR ALBINISM - LINKAGE ANALYSIS IN A LARGE NEWFOUNDLAND KINDRED

被引：19

作者：

CHARLES, SJ

GREEN, JS

MOORE, AT

BARTON, DE

YATES, JRW

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,MOLEC GENET DIAGNOST LAB,CAMBRIDGE CB2 2QQ,ENGLAND

[2] MEM UNIV NEWFOUNDLAND,ST JOHNS A1C 5S7,NEWFOUNDLAND,CANADA

[3] MEM UNIV NEWFOUNDLAND,DEPT OPHTHALMOL,ST JOHNS A1C 5S7,NEWFOUNDLAND,CANADA

[4] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT CLIN GENET,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

GENOMICS | 1993年 / 16卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/geno.1993.1171

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genetic linkage studies in a large Newfoundland family affected by X-linked ocular albinism (OA1) showed linkage to markers from Xp22.3. One recombinant mapped the disease proximal to DXS143 (dic56) and two recombinants mapped the disease distal to DXS85 (782). Combining the data with that from 16 British families previously published confirmed close linkage between OA1 and DXS143 (dic56;Z(max)=21.96 at θ=0.01, confidence interval (CI) 0.00050-0.05) and linkage to DXS85 (782;Z(max)=17.60 at θ=0.07, CI=0.03-0.13) and DXS237 (GMGX9;Z(max)=15.20 at θ=0.08, CI = 0.03-0.15). Multipoint analysis (LINKMAP) gave the most likely order as Xpter-XG-DXS237-DXS 143-OA1-DXS85, with odds of 48:1 over the order Xpter-XG-DXS237-OA1-DXS143-DXS85, and odds exceeding 1010:1 over other locations for the disease locus. © 1993 Academic Press, Inc.

引用

页码：259 / 261

页数：3

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