LOCALIZATION OF THE NUCLEOTIDE EXCISION REPAIR GENE ERCC6 TO HUMAN-CHROMOSOME 10Q11-Q21

被引：32

作者：

TROELSTRA, C

LANDSVATER, RM

WIEGANT, J

VANDERPLOEG, M

VIEL, G

BUYS, CHCM

HOEIJMAKERS, JHJ

机构：

[1] ERASMUS UNIV, CTR MED GENET, DEPT CELL BIOL & GENET, POB 1738, 3000 DR ROTTERDAM, NETHERLANDS

[2] UNIV GRONINGEN, DEPT MED GENET, 9700 AB GRONINGEN, NETHERLANDS

[3] SYLVIUS LAB, DEPT CYTOCHEM & CYTOMETRY, LEIDEN, NETHERLANDS

来源：

GENOMICS | 1992年 / 12卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90304-B

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster ovary cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse × human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis. © 1992.

引用

页码：745 / 749

页数：5

共 29 条

[1] SUMMARY OF COMPLEMENTATION GROUPS OF UV-SENSITIVE CHO-CELL MUTANTS ISOLATED BY LARGE-SCALE SCREENING [J].