ABSORBABLE SELF-REINFORCED POLYLACTIDE (SR-PLA) COMPOSITE RODS FOR FRACTURE FIXATION - STRENGTH AND STRENGTH RETENTION IN THE BONE AND SUBCUTANEOUS TISSUE OF RABBITS

被引：109

作者：

MAJOLA, A

VAINIONPAA, S

ROKKANEN, P

MIKKOLA, HM

TORMALA, P

机构：

[1] The Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Helsinki

[2] Biomaterials Laboratory, Institute of Plastics Technology, Tampere University of Technology, Tampere

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1992年 / 3卷 / 01期

关键词：

D O I：

10.1007/BF00702943

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The strength and strength retention of self-reinforced (SR) absorbable polylactic acid composite rods were evaluated after intramedullary and subcutaneous implantation in rabbits. Rods made of poly-l-lactic acid (SR-PLLA) and of poly-dl-lactic acid + poly-l-lactic acid composite (SR-PDLLA/PLLA) were used. The molecular mass (M(v) of PLLA was 260.000 and that of PDLLA 100.000. The bending and shear strengths were measured after a follow-up of 1-48 weeks. The initial bending strength of the SR-PLLA rods was 250-271 MPa and the shear strength was 94-98 MPa. After intramedullary and subcutaneous implantation of 12 weeks the bending strength of the SR-PLLA implants was 100 MPa. At 36 weeks the bending strength had decreased to the level of the strength of cancellous bone (10-20 MPa). There were no changes in the shear strength during 12 weeks hydrolysis. The initial bending strength of SR-PDLLA/PLLA implants was 209 MPa and during the follow-up the implants lost their bending and shear strength faster than the SR-PLLA implants. The present investigation gave us the impetus to continue the studies with the fixation of experimental cortical bone osteotomies with SR-PLLA intramedullary rods.

引用

页码：43 / 47

页数：5

共 29 条

[1]

Kulkarni R.K., Pani K.C., Neuman C., Leonard F., Arch. Surg., 93, (1966)

[2]

Frazza E.J., Schmitt E.E., J. Biomed. Mater. Res. Symp., 1, (1971)

[3]

Willia D.F., A.S.T.M. Spec. Tech. Publ., 684, (1979)

[4]

Willia D.F., J. Mater. Sci., 17, (1982)

[5]

Lehninger A.L., Principles of biochemistry, (1982)

[6]

Hollinger J.O., J. Biomed. Mater. Res., 17, (1983)

[7]

Hollinger J.O., Battistone B.C., Clin. Orthop., 207, (1986)

[8]

Vainionpaa S., Rokkanen P., Tormala P., Prog. Polym. Sci., 14, (1989)

[9]

Leenslag J.W., Poly(l-lactide) and its biomedical applications, (1987)

[10]

Brady J.M., Cutright D.E., Miller R.A., Battistone G.C., J. Biomed. Mater. Res., 7, (1973)

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