TUMOR-NECROSIS-FACTOR RECEPTOR GENES, TNFR1 AND TNFR2, ON HUMAN CHROMOSOME-12 AND CHROMOSOME-1

被引：21

作者：

MILATOVICH, A

SONG, K

HELLER, RA

FRANCKE, U

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305

[2] SYNTEX INC,INST CANC & DEV BIOL,PALO ALTO,CA 94304

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1991年 / 17卷 / 05期

关键词：

D O I：

10.1007/BF01233176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human x Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12.

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页码：519 / 523

页数：5

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