URINARY MARKERS OF CHRONIC EXCESSIVE ETHANOL-CONSUMPTION

被引：4
作者：
TANG, BK
机构：
[1] Department of Pharmacology, University of Toronto, Toronto, Ontario, Medical Sciences Building
来源：
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1991年 / 15卷 / 05期
关键词：
ETHANOL; MARKERS; CONJUGATES; CONSUMPTION; ACETALDEHYDE;
D O I：
10.1111/j.1530-0277.1991.tb00618.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
A gas chromatographic mass spectrometric procedure is described for the measurement of free ethanol and conjugates of ethanol and acetaldehyde. It was demonstrated that conjugates of ethanol and acetaldehyde were present in urine of alcoholics. Urinary levels of free ethanol and the conjugates in abstaining alcoholics were higher than those of social drinkers. On the average, alcoholics excreted equal amounts of free ethanol and ethanol conjugates while controls eliminated three parts of ethanol conjugates to one part of free ethanol. After 14 days of abstinence, 16/23 (70%) of alcoholics had levels of free ethanol and acetaldehyde conjugates higher than the mean +2 SD Of social drinkers for these substances. When the molar ratio of ethanol conjugates/free ethanol was considered, five more subjects who were alcoholics could be classified as being alcoholics. There was one false positive among 46 control subjects.
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页码：881 / 885
页数：5
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