ENKEPHALIN DEGRADATION IN MOUSE-BRAIN STUDIED BY A NEW HPLC METHOD - FURTHER EVIDENCE FOR THE INVOLVEMENT OF CARBOXYDIPEPTIDASE

被引：59
作者：
GUYON, A
ROQUES, BP
GUYON, F
FOUCAULT, A
PERDRISOT, R
SWERTS, JP
SCHWARTZ, JC
机构：
[1] UNIV PARIS 5,DEPT CHIM ORGAN,F-75270 PARIS 06,FRANCE
[2] ECOLE SUPER PHYS & CHIM IND,CHIM ANAL LAB,F-75231 PARIS 05,FRANCE
[3] INSERM,CHIM ANAL LAB,F-75014 PARIS,FRANCE
[4] INSERM,UNITE 109,F-75014 PARIS,FRANCE
来源：
LIFE SCIENCES | 1979年 / 25卷 / 18期
关键词：
D O I：
10.1016/0024-3205(79)90444-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The degradation of the Met-enkephalin by peptidases present in striatum extracts was followed by a new H.P.L.C. method, based on ligand exchange chromatography. An aminopeptidase activity is present in both the soluble and the particulate fractions of mouse striatum. In addition we confirmed the presence, mainly in the particulate fraction, of a carboxydipeptidase releasing TyrGlyGly and PheMet from Met-enkephalin. The tetrapeptide GlyGlyPheMet also appears to be cleaved by the same enzyme activity. © 1979.
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页码：1605 / 1611
页数：7
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