STIMULATION OF PROLACTIN-RELEASE BY INTRAVENOUS CIMETIDINE - DOSE-RESPONSE STUDY

被引：26

作者：

CALDARA, R

BIERTI, L

BARBIERI, C

CAMBIELLI, M

ROMUSSI, M

FERRARI, C

机构：

[1] 2nd Department of Medicine, Department of Nuclear Medicine, Fatebenefratelli Hospital, Milano

[2] 3rd Medical Clinic, University of Milano, Milano

[3] 2A Divisione Medica, Ospedale Fatebenefratelli, Milano, 20121

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1979年 / 2卷 / 01期

关键词：

Cimetidine; healthy man; prolactin dose-response curve;

D O I：

10.1007/BF03349280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The PRL response to iv cimetidine was tested in 8 healthy males and 8 females at 4 different dose levels (0.75, 1.5, 3.0 and 6.0 mg/kg bw). Serum PRL levels were significantly increased in comparison with a placebo study by the second cimetidine dose in both sexes. The PRL response was significantly higher in females than in males at all but the lowest dose tested. A significant correlation between the cimetidine dose and the PRL response was observed. There were no significant modifications in serum GH, LH, FSH, IRI and glucose. Present findings demonstrate that the stimulation of PRL release by iv cimetidine is quite specific and dose-dependent. © 1979, Italian Society of Endocrinology (SIE). All rights reserved.

引用

页码：79 / 81

页数：3