Vascular Disaggregation Control Of Neutrophils In Patients With Arterial Hypertension With Impaired Glucose Tolerance

Despite the efforts of medicine among the population of industrially developed countries, arterial hypertension and violation of glucose tolerance are very widespread. It is recognized that the high prevalence of thromboses in arterial hypertension and impaired glucose tolerance is associated with a weakening of the vascular functions and, in the first place, their disaggregation effects on the blood elements. The goal is to clarify the disaggregation capabilities of the vessels in relation to neutrophils in patients with arterial hypertension with impaired glucose tolerance. We examined 49 patients of the second mature age (mean age 52.4 +/- 1.9 years) with arterial hypertension of the 1st-2nd degree, with impaired glucose tolerance. The control group was composed of 26 clinically healthy people of the same age. All the examined persons gave written informed consent on participation in the research. There were applied biochemical, hematological and statistical methods of investigation. High thromboses' frequency of various localizations at arterial hypertension with impaired glucose tolerance is closely connected with angiopathy development against their background. Weakening of plasma antioxidant protection with activation of lipids' peroxidation processes in it leading to alteration of vascular wall, is noted in conditions of arterial hypertension combination with impaired glucose tolerance. The persons with arterial hypertension and impaired glucose tolerance are detected to have evident weakening of disaggregating vascular impacts of vascular wall on strengthening aggregative ability of neutrophils. In the result of it given patients get sharply increased risk of thromboses of any localization which can lead to invalidism and lethal outcome.