ACTIVE MICROGLIA, SICK ASTROGLIA AND ALZHEIMER-TYPE DEMENTIAS

被引：36
作者：
NIETOSAMPEDRO, M [1 ]
MORA, F [1 ]
机构：
[1] UNIV MADRID, SCH MED, DEPT PHYSIOL, MADRID, SPAIN
来源：
NEUROREPORT | 1994年 / 5卷 / 04期
关键词：
MICROGLIA; ASTROGLIA; ALZHEIMERS DISEASE; AMYLOID; CALCIUM; TAU PROTEIN; APOLIPOPROTEIN E; AXONAL TRANSPORT; NEURODEGENERATION; GLUTAMATE; IL-1;
D O I：
10.1097/00001756-199401120-00001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We propose that Alzheimer's disease is initiated by failure of axonal transport. After the neurodegeneration cascade is initiated, microglial and astroglial cells have major roles in directly and indirectly promoting self-sustaining neurodegeneration cycles. This hypothesis makes testable predictions and suggests logical therapies.
引用
收藏
页码：375 / 380
页数：6
相关论文
共 106 条
[1]  
ABAD J, 1993, EUR NEUR ASS ABSTR, V16, P23
[2]   BETA-AMYLOID STIMULATES GLIAL-CELLS INVITRO TO PRODUCE GROWTH-FACTORS THAT ACCUMULATE IN SENILE PLAQUES IN ALZHEIMERS-DISEASE [J].
ARAUJO, DM ;
COTMAN, CW .
BRAIN RESEARCH, 1992, 569 (01) :141-145
[3]   CHARACTERIZATION AND SYNTHESIS OF A MACROPHAGE INHIBITORY PEPTIDE FROM THE 2ND CONSTANT DOMAIN OF HUMAN IMMUNOGLOBULIN-G [J].
AURIAULT, C ;
JOSEPH, M ;
TARTAR, A ;
CAPRON, A .
FEBS LETTERS, 1983, 153 (01) :11-15
[4]  
AVILA J, 1993, NEUROANAL DEATH REPA, pCH5
[5]   CYTOTOXICITY OF MICROGLIA [J].
BANATI, RB ;
GEHRMANN, J ;
SCHUBERT, P ;
KREUTZBERG, GW .
GLIA, 1993, 7 (01) :111-118
[6]   SOLUTION STRUCTURES OF BETA PEPTIDE AND ITS CONSTITUENT FRAGMENTS - RELATION TO AMYLOID DEPOSITION [J].
BARROW, CJ ;
ZAGORSKI, MG .
SCIENCE, 1991, 253 (5016) :179-182
[7]   MOUSE MACROPHAGES SYNTHESIZE AND SECRETE A PROTEIN RESEMBLING APOLIPOPROTEIN-E [J].
BASU, SK ;
BROWN, MS ;
HO, YK ;
HAVEL, RJ ;
GOLDSTEIN, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7545-7549
[8]  
BAUDIER J, 1987, J BIOL CHEM, V262, P17577
[9]   DISPLACEMENT OF SYNAPTIC TERMINALS FROM REGENERATING MOTONEURONS BY MICROGLIAL CELLS [J].
BLINZING.K ;
KREUTZBE.G .
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE, 1968, 85 (02) :145-&
[10]   THE GLIAL-CELL GLUTAMATE UPTAKE CARRIER COUNTERTRANSPORTS PH-CHANGING ANIONS [J].
BOUVIER, M ;
SZATKOWSKI, M ;
AMATO, A ;
ATTWELL, D .
NATURE, 1992, 360 (6403) :471-474
12345678910