RETINOBLASTOMA AND P53 GENE-EXPRESSION RELATED TO RELAPSE AND SURVIVAL IN HUMAN BREAST-CANCER - AN IMMUNOHISTOCHEMICAL STUDY

被引:85
作者
SAWAN, A [1 ]
RANDALL, B [1 ]
ANGUS, B [1 ]
WRIGHT, C [1 ]
HENRY, JA [1 ]
OSTROWSKI, J [1 ]
HENNESSY, C [1 ]
LENNARD, TWJ [1 ]
CORBETT, I [1 ]
HORNE, CHW [1 ]
机构
[1] ROYAL VICTORIA INFIRM,DEPT CLIN SURG,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
关键词
RETINOBLASTOMA GENE; P53; ONCOPROTEINS; ONCOSUPPRESSOR GENES; BREAST CANCER; IMMUNOHISTOCHEMISTRY;
D O I
10.1002/path.1711680105
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inactivation of tumour suppressor genes may be an important aetiological factor in many human cancers including breast. In a study of 197 breast cancer patients, tumour tissue was snap-frozen at the time of surgery and immunohistochemical labelling for p53 protein and retinoblastoma (Rb) gene product carried out using an indirect immunohistochemical technique. Tumours were scored by two independent observers for the intensity of nuclear staining for each antibody. Expression of p53 protein showed a significant association with a shorter time to relapse (P=0-03) and death (P=0.02) (log rank test). p53 expression did not correlate with nodal status but showed a significant association with high tumour grade (P=0.001). Rb gene expression showed no relationship to relapse or survival but loss of expression showed a significant correlation with positive lymph node status. The manner by which these proteins might act to determine tumour behaviour remains to be established.
引用
收藏
页码:23 / 28
页数:6
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