POLAROGRAPHIC ASSAY OF NIACINAMIDE IN PHARMACEUTICAL PREPARATIONS

被引：8

作者：

MOORE, JM

机构：

[1] Baltimore District Laboratories, Food and Drug Administration, Baltimore, Maryland, 21201

[2] Bureau of Narcotics and Dangerous Drugs, Department of Justice, Washington, District of Columbia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Column; liquid‐liquid partition chromatography–extraction; Niacinamide dosage forms–analysis; Polaropraphy–analysis;

D O I：

10.1002/jps.2600580917

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid polarographic determination of niacinamide pharmaceutical preparations had been developed and is compared with the König colorimetric assay using barbituric acid. The niacinamide is extracted from the sample using a combination column and liquid‐liquid partition chromatography. The extracted niacinamide is determined in a supporting electrolyte of 0.1 N sodium hydroxide using a conventional d.c. polarograph equipped with an H‐cell. A wide variety of samples was analyzed repetitively by this procedure and the standard deviation was calculated. The method is rapid, specific, and accurate. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1117 / &

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