ELASTASE INHIBITORS CONTAINING CONFORMATIONALLY RESTRICTED LACTAMS AS P-3-P-2 DIPEPTIDE REPLACEMENTS

被引：44
作者：
SKILES, JW
SORCEK, R
JACOBER, S
MIAO, C
MUI, PW
MCNEIL, D
ROSENTHAL, AS
机构：
[1] Department of Medicinal Chemistry Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)81273-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.
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收藏
页码：773 / 778
页数：6
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