NEW ROUTE TO PYROGLUTAMATES VIA ALPHA-CHLORO AMIDE RADICAL CYCLIZATION

被引：30

作者：

GOODALL, K ^{[1
]}

PARSONS, AF ^{[1
]}

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 22期

关键词：

D O I：

10.1039/p19940003257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tributyltin hydride mediated radical cyclisation of N-(alpha-chloroacetamido)dehydroalanine derivatives prepared from serine proceeds regioselectively to give pyroglutamates in 47-74% yield-the cyclisation of the intermediate carbamoylmethyl radical proceeds in a 'disfavoured' 5-endo-trig manner.

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页码：3257 / 3259

页数：3

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