Internal initiation of translation

被引：39

作者：

McBratney, Susan ^{[1
]}

Chen, Chang You ^{[1
]}

Sarnow, Peter ^{[1
]}

机构：

[1] Univ Colorado, HSC, Dept Biochem Biophys & Genet, Denver, CO 80262 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0955-0674(93)90077-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the 5' cap-dependent scanning mechanism can account for the translational initiation of most mRNAs in eukaryotic cells, several viral and cellular mRNAs contain nucleotide sequences in their 5' non-coding regions that can mediate binding of ribosomes to the mRNA, regardless of the modification state of the 5' ends. During the past year, some nuclear proteins normally involved in RNA processing have been shown also to facilitate 'internal' ribosome binding. Unexpected dual functions have, therefore, been suggested for these RNA-binding proteins, in both RNA biogenesis in the nucleus and RNA translation in the cytoplasm.

引用

页码：961 / 965

页数：5

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