NMR-STUDIES OF THE NA+, MG2+ AND CA2+ COMPLEXES OF CYCLOSPORINE-A

被引：27
作者：
CARVER, JA
REES, NH
TURNER, DL
SENIOR, SJ
CHOWDHRY, BZ
机构：
[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND
[2] UNIV WOLLONGONG,DEPT CHEM,WOLLONGONG,NSW 2522,AUSTRALIA
[3] UNIV GREENWICH,SCH BIOL & CHEM SCI,LONDON SE18 6PF,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 22期
关键词：
D O I：
10.1039/c39920001682
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The immunosuppressant cyclosporin A has been shown by NMR spectroscopy to form complexes with Na+, Ca2+ and Mg2+ in acetonitrile; Ca2+ and Mg2+ form 1 : 1 complexes and the conformation of cyclosporin A changes dramatically upon binding of the metal ions.
引用
收藏
页码：1682 / 1684
页数：3
相关论文
共 13 条
  • [1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
    BAX, A
    SUMMERS, MF
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
  • [2] BLICK KE, 1985, PRINCIPLES CLIN CHEM
  • [3] NMR-STUDIES OF [U-C-13]CYCLOSPORIN-A BOUND TO CYCLOPHILIN - BOUND CONFORMATION AND PORTIONS OF CYCLOSPORINE INVOLVED IN BINDING
    FESIK, SW
    GAMPE, RT
    EATON, HL
    GEMMECKER, G
    OLEJNICZAK, ET
    NERI, P
    HOLZMAN, TF
    EGAN, DA
    EDALJI, R
    SIMMER, R
    HELFRICH, R
    HOCHLOWSKI, J
    JACKSON, M
    [J]. BIOCHEMISTRY, 1991, 30 (26) : 6574 - 6583
  • [4] PEPTIDE CONFORMATIONS .30. ASSIGNMENT OF THE H-1-NMR, C-13-NMR, AND N-15-NMR SPECTRA OF CYCLOSPORIN-A IN CDCL3 AND C6D6 BY A COMBINATION OF HOMONUCLEAR AND HETERONUCLEAR TWO-DIMENSIONAL TECHNIQUES
    KESSLER, H
    LOOSLI, HR
    OSCHKINAT, H
    [J]. HELVETICA CHIMICA ACTA, 1985, 68 (03) : 661 - 681
  • [5] REINVESTIGATION OF THE CONFORMATION OF CYCLOSPORINE-A IN CHLOROFORM
    KESSLER, H
    KOCK, M
    WEIN, T
    GEHRKE, M
    [J]. HELVETICA CHIMICA ACTA, 1990, 73 (07) : 1818 - 1832
  • [6] KOCK M, 1992, J AM CHEM SOC, V114, P2676
  • [7] PEPTIDE CONFORMATIONS .31. THE CONFORMATION OF CYCLOSPORIN-A IN THE CRYSTAL AND IN SOLUTION
    LOOSLI, HR
    KESSLER, H
    OSCHKINAT, H
    WEBER, HP
    PETCHER, TJ
    WIDMER, A
    [J]. HELVETICA CHIMICA ACTA, 1985, 68 (03) : 682 - 704
  • [8] IMPROVED TECHNIQUES FOR HOMONUCLEAR ROTATING-FRAME AND ISOTROPIC MIXING EXPERIMENTS
    RANCE, M
    [J]. JOURNAL OF MAGNETIC RESONANCE, 1987, 74 (03): : 557 - 564
  • [9] SENIOR SJ, 1992, UNPUB BIOPHYS CHEM
  • [10] COMPLETE H-1 AND C-13 ASSIGNMENTS OF COENZYME-B12 THROUGH THE USE OF NEW TWO-DIMENSIONAL NMR EXPERIMENTS
    SUMMERS, MF
    MARZILLI, LG
    BAX, A
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (15) : 4285 - 4294
12