NMR-STUDIES OF THE NA+, MG2+ AND CA2+ COMPLEXES OF CYCLOSPORINE-A

被引：27

作者：

CARVER, JA

REES, NH

TURNER, DL

SENIOR, SJ

CHOWDHRY, BZ

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

[2] UNIV WOLLONGONG,DEPT CHEM,WOLLONGONG,NSW 2522,AUSTRALIA

[3] UNIV GREENWICH,SCH BIOL & CHEM SCI,LONDON SE18 6PF,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 22期

关键词：

D O I：

10.1039/c39920001682

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The immunosuppressant cyclosporin A has been shown by NMR spectroscopy to form complexes with Na+, Ca2+ and Mg2+ in acetonitrile; Ca2+ and Mg2+ form 1 : 1 complexes and the conformation of cyclosporin A changes dramatically upon binding of the metal ions.

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页码：1682 / 1684

页数：3

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