EFFECT OF DURATION OF HEPATITIS-B VIRUS-INFECTION ON THE ASSOCIATION BETWEEN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND HEPATITIS-B VIRAL REPLICATION

被引：33

作者：

KOBLIN, BA ^{[1
]}

TAYLOR, PE ^{[1
]}

RUBINSTEIN, P ^{[1
]}

STEVENS, CE ^{[1
]}

机构：

[1] NEW YORK BLOOD CTR,IMMUNOGENET LAB,NEW YORK,NY 10021

来源：

HEPATOLOGY | 1992年 / 15卷 / 04期

关键词：

D O I：

10.1002/hep.1840150406

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study examined the effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type-1 infection and hepatitis B viral replication. Twenty-five chronic HBsAg carriers were studied. Presence of hepatitis B virus DNA and expression of HBeAg were more frequent among 20 chronic HBsAg carriers positive for human immunodeficiency virus type-1 antibody compared with five chronic HBsAg carriers negative for human immunodeficiency virus type-1 antibody, but the associations were not statistically significant. Hepatitis B virus DNA and HBeAg were inversely related to duration of hepatitis B virus infection (p < 0.001). Stratifying for duration of hepatitis B virus infection, the presence of viral replication was similar among patients negative and positive for antibody to human immunodeficiency virus type-1. Hepatitis B virus DNA levels did not increase with the decline of cellular immunity over time. In conclusion, hepatitis B virus replication among chronic carriers may be a function of duration of hepatitis B virus infection rather than of an effect of human immunodeficiency virus type-1.

引用

页码：590 / 592

页数：3

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