SAFE DISPOSAL OF DIISOPROPYL FLUOROPHOSPHATE (DFP)

被引：5
|
作者：
LUNN, G
SANSONE, EB
机构：
[1] NCI-Frederick Cancer Research and Development Center, Program Resources, Inc./DynCorp, Environmental Control and Research Program, Frederick, 21702-1201, MD, P.O. Box B
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 1994年 / 49卷 / 02期
关键词：
SAFETY; DEGRADATION; STABILITY; ENZYME INHIBITOR; DIISOPROPYL FLUOROPHOSPHATE; DYFLOS; ISOFLUROPHATE;
D O I：
10.1007/BF02788550
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diisopropyl fluorophosphate (DFP), a volatile highly toxic enzyme inhibitor, in buffer (pH 3, pH 5, pH 7, pH 9, pH 11, Hank's, Dulbecco's, PBS, TBE, and HEPES) or water (10 mM), in DMF solution (200 mM), and bulk quantities can be degraded by adding 1M NaOH. The DFP was completely degraded, as determined by enzymatic assay, and the final reaction mixtures were not mutagenic.
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页码：165 / 172
页数：8
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