Exposure to Tamoxifen During Pregnancy

Breast cancer is the most frequent cancer type in women worldwide. It is treated by surgery, chemotherapy, radiation therapy or in combination of these modalities. For the adjuvant treatment, tamoxifen is used widely. Pregnancy can occur during tamoxifen treatment in the premenoposal patients. But, there is not sufficient data on the safety of tamoxifen during pregnancy. So, here we presented a case with usage of tamoxifen until the 16th week of pregnancy. The patient was followed and delivered at the 38th week of pregnancy. No fetal anomalies were observed in this case in the following three years. In the review of the literature addressing tamoxifen exposure during pregnancy, many studies are laboratory based and there areonly a few reports about human pregnancy. Tamoxifen may be potentionally teratogenic, but this effect has not been often observed in humans. So, exposure to tamoxifen during pregnancy may not have a serious effect on the fetus.