IMPACT OF POLYCHLORINATED DIBENZO-P-DIOXINS, DIBENZOFURANS, AND BIPHENYLS ON HUMAN AND ENVIRONMENTAL-HEALTH, WITH SPECIAL EMPHASIS ON APPLICATION OF THE TOXIC EQUIVALENCY FACTOR CONCEPT

被引：184

作者：

AHLBORG, UG

BROUWER, A

FINGERHUT, MA

JACOBSON, JL

JACOBSON, SW

KENNEDY, SW

KETTRUP, AAF

KOEMAN, JH

POIGER, H

RAPPE, C

SAFE, SH

SEEGAL, RF

TUOMISTO, J

VANDENBERG, M

机构：

[1] KAROLINSKA INST, INST ENVIRONM MED, S-10401 STOCKHOLM 60, SWEDEN

[2] AGR UNIV WAGENINGEN, DEPT TOXICOL, 6700 HB WAGENINGEN, NETHERLANDS

[3] NIOSH, CINCINNATI, OH 45226 USA

[4] WAYNE STATE UNIV, DEPT PSYCHOL, DETROIT, MI 48202 USA

[5] ENVIRONM CANADA, CANADIAN WILDLIFE SERV, HULL, PQ, CANADA

[6] GESELL STRAHLENFORSCH, INST OKOL, NEUHERBERG, GERMANY

[7] UNIV ZURICH, INST TOXICOL, CH-8603 SCHWERZENBACH, SWITZERLAND

[8] UMEA UNIV, INST ENVIRONM CHEM, S-90187 UMEA, SWEDEN

[9] TEXAS A&M UNIV SYST, DEPT VET PHYSIOL & PHARMACOL, COLL STN, TX 77843 USA

[10] NEW YORK STATE DEPT HLTH, WADSWORTH CTR, ALBANY, NY 12201 USA

[11] NATL PUBL HLTH INST, DIV ENVIRONM HLTH, KUOPIO, FINLAND

[12] UNIV UTRECHT, TOXICOL RES INST, UTRECHT, NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1992年 / 228卷 / 04期

关键词：

POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS); POLYCHLORINATED DIBENZOFURANS (PCDFS); POLYCHLORINATED BIPHENYLS (PCBS); AH RECEPTORS; AH (ARYL-HYDROCARBON)-MEDIATED EFFECTS; NON-AH (ARYL-HYDROCARBON)-MEDIATED EFFECTS; TOXIC EQUIVALENCY FACTOR (TEF); RISK MANAGEMENT; NEUROBEHAVIORAL RESPONSES; CARCINOGENICITY; ENDOCRINE RESPONSES; KINETICS; METABOLISM; SPECIES DIFFERENCES;

D O I：

10.1016/0926-6917(92)90029-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

引用

页码：179 / 199

页数：21

共 185 条

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