6-METHOXY-2-METHYLSULFONYLQUINOLINE-4-CARBONYL CHLORIDE AS A FLUORESCENCE DERIVATIZATION REAGENT FOR ALCOHOLS IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：12
作者：
YOSHIDA, T
MORIYAMA, Y
TANIGUCHI, H
机构：
[1] Meiji College of Pharmacy, Nozawa, Setagaya
来源：
ANALYTICAL SCIENCES | 1992年 / 8卷 / 03期
关键词：
PRIMARY ALCOHOL; SECONDARY ALCOHOL; PHENOL; 6-METHOXY-2-METHYLSULFONYLQUINOLINE-4-CARBONYL CHLORIDE; FLUORESCENCE DERIVATIZATION REAGENT; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;
D O I：
10.2116/analsci.8.355
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
6-Methoxy-2-methylsulfonylquinoline-4-carbonyl chloride was found to be a highly sensitive fluorescence derivatization reagent for both primary and secondary alcohols in high-performance liquid chromatography. Its reactivity was investigated for 1-propanol, benzyl alcohol, cyclohexanol, and 1-hexanol. The reagent reacted with the alcohols or phenol in benzene in the presence of pyridine to produce the corresponding fluorescent esters, which could be separated on a reversed-phase column, Cosmosil 5C18-AR, with aqueous 70% (v/v) acetonitrile. The detection limits (S/N=3) were 0.07 pmol for 1-propanol, 0.1 pmol for 1-hexanol and for benzyl alcohol, and 0.7 pmol for cyclohexanol for an injection volume of 10-mu-l.
引用
收藏
页码：355 / 359
页数：5
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