THE YEAST PUTATIVE TRANSCRIPTIONAL REPRESSOR RGM1 IS A PROLINE-RICH ZINC FINGER PROTEIN

被引：24
作者：
ESTRUCH, F
机构：
[1] Departament de Bioquímica i Biologia Molecular, Universitat de Valéncia
来源：
NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 18期
关键词：
D O I：
10.1093/nar/19.18.4873
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonine content, suggesting that RGM1 and Egr proteins could have functional similarities.
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收藏
页码：4873 / 4877
页数：5
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