POTENTIATION OF ACETALDEHYDE-INDUCED VASOCONSTRICTIONS BY COCAINE IN ISOLATED AND PERFUSED ARTERIES

被引：2
|
作者：
CHIBA, S
TSUKADA, M
机构：
[1] Department of Pharmacology, Shinshu University School of Medicine
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 165卷 / 01期
关键词：
ACETALDEHYDE; COCAINE; CANNULA INSERTING METHOD;
D O I：
10.1620/tjem.165.63
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vasoconstrictor responses to acetaldehyde (AA), norepinephrine (NE) and tyramine were investigated in isolated, perfused canine intermediate auricular (ear) arteries. Single injections of small doses of AA (1-3-mu-mol) induced a vasoconstriction in a dose-related manner and showed no tachyphylaxis. Cocaine significantly inhibited tyramine-induced vasoconstrictions, but NE- and AA-induced vasoconstrictions were rather significantly enhanced.
引用
收藏
页码：63 / 65
页数：3
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