L-ASPARAGINASE EFFECT ON ANTI-THROMBIN-III LEVELS

被引：30

作者：

ANDERSON, N ^{[1
]}

LOKICH, JJ ^{[1
]}

TULLIS, JL ^{[1
]}

机构：

[1] NEW ENGLAND DEACONESS HOSP,DEPT MED ONCOL,BOSTON,MA 02215

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 04期

关键词：

antithrombin‐111; lymphoblastic leukemia; L‐asparaginase;

D O I：

10.1002/mpo.2950070408

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of L‐asparaginase (L‐asp) therapy on circulating antithrombin‐III (AT‐III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT‐III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT‐III levels, followed by a protracted recovery beyond the period of L‐asp exposure. One of the three patients developed a reversible venous thrombosis of the arm. The mechanism of the L‐asparaginase effect may be related to peripheral degradation of AT‐III or to inhibition of production. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：335 / 340

页数：6

共 17 条

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