CHRONIC NEUTROPHILIC LEUKEMIA AND MULTIPLE-MYELOMA - AN ASSOCIATION WITH LAMBDA-LIGHT CHAIN EXPRESSION

被引：2
|
作者：
STANDEN, GR [1 ]
JASANI, B [1 ]
WAGSTAFF, M [1 ]
WARDROP, CAJ [1 ]
机构：
[1] UNIV COLL CARDIFF,DEPT PATHOL,CARDIFF CF4 4XN,S GLAM,WALES
来源：
CANCER | 1990年 / 66卷 / 01期
关键词：
D O I：
10.1002/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-Z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed. Copyright © 1990 American Cancer Society
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页码：162 / 166
页数：5
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