ENHANCEMENT OF HIPPOCAMPAL EXCITATORY SYNAPTIC TRANSMISSION BY PLATELET-ACTIVATING-FACTOR

被引:193
作者
CLARK, GD
HAPPEL, LT
ZORUMSKI, CF
BAZAN, NG
机构
[1] LOUISIANA STATE UNIV, MED CTR, SCH MED, DEPT NEUROSURG, NEW ORLEANS, LA 70112 USA
[2] LOUISIANA STATE UNIV, MED CTR, SCH MED, DEPT OPHTHALMOL, NEW ORLEANS, LA 70112 USA
[3] LOUISIANA STATE UNIV, MED CTR, SCH MED, DEPT PEDIAT, NEW ORLEANS, LA 70112 USA
[4] LOUISIANA STATE UNIV, MED CTR, SCH MED, DEPT PHYSIOL, NEW ORLEANS, LA 70112 USA
[5] LOUISIANA STATE UNIV, MED CTR, SCH MED, CTR NEUROSCI, NEW ORLEANS, LA 70112 USA
[6] WASHINGTON UNIV, SCH MED, DEPT PSYCHIAT, ST LOUIS, MO 63110 USA
[7] WASHINGTON UNIV, SCH MED, DEPT ANAT & NEUROBIOL, ST LOUIS, MO 63110 USA
关键词
D O I
10.1016/0896-6273(92)90078-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The biologically active lipid platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine; PAF) is a mediator of inflammatory and immune responses, and it accumulates in the brain during convulsions or ischemia. We have examined whether PAF may play a second messenger role in the central nervous system by studying effects on synaptic transmission in cultured hippocampal neurons. Carbamyl-PAF, a nonhydrolyzable PAF analog with a similar pharmacologic profile, augmented glutamate-mediated, evoked excitatory synaptic transmission and increased the frequency of spontaneous miniature excitatory synaptic events without increasing their amplitude or altering their time course. This compound had no significant effect on gamma-aminobutyric acid-mediated inhibitory synaptic responses. Lyso-PAF, the biologically inactive metabolic intermediate, had no effect on synaptic transmission. Moreover, the enhancement of excitatory synaptic transmission by carbamyl-PAF was blocked by a PAF receptor antagonist. These results indicate a specific presynaptic effect of PAF in enhancing excitatory synaptic transmission in cultured rat hippocampal neurons.
引用
收藏
页码:1211 / 1216
页数:6
相关论文
共 36 条
[1]   ANTAGONISTS OF THE PLATELET-ACTIVATING-FACTOR RECEPTOR BLOCK LONG-TERM POTENTIATION IN HIPPOCAMPAL SLICES [J].
ARAI, A ;
LYNCH, G .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (05) :411-419
[2]   PLATELET-ACTIVATING-FACTOR AND POLYUNSATURATED FATTY-ACIDS IN CEREBRAL-ISCHEMIA OR CONVULSIONS - INTRACELLULAR PAF-BINDING SITES AND ACTIVATION OF A FOS/JUN/AP-1 TRANSCRIPTIONAL SIGNALING SYSTEM [J].
BAZAN, NG ;
SQUINTO, SP ;
BRAQUET, P ;
PANETTA, T ;
MARCHESELLI, VL .
LIPIDS, 1991, 26 (12) :1236-1242
[3]  
BAZAN NG, 1989, ANN NY ACAD SCI, V559, P1
[5]   FREE FATTY ACID PRODUCTION IN CEREBRAL WHITE AND GREY MATTER OF SQUIRREL MONKEY [J].
BAZAN, NG .
LIPIDS, 1971, 6 (03) :211-&
[6]   PRESYNAPTIC MECHANISM FOR LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BEKKERS, JM ;
STEVENS, CF .
NATURE, 1990, 346 (6286) :724-729
[7]   PLATELET-ACTIVATING FACTOR ANTAGONIST BN52021 DECREASES ACCUMULATION OF FREE POLY-UNSATURATED FATTY-ACID IN MOUSE-BRAIN DURING ISCHEMIA AND ELECTROCONVULSIVE SHOCK [J].
BIRKLE, DL ;
KURIAN, P ;
BRAQUET, P ;
BAZAN, NG .
JOURNAL OF NEUROCHEMISTRY, 1988, 51 (06) :1900-1905
[8]   EFFECT OF BICUCULLINE-INDUCED STATUS EPILEPTICUS ON PROSTAGLANDINS AND HYDROXYEICOSATETRAENOIC ACIDS IN RAT-BRAIN SUBCELLULAR-FRACTIONS [J].
BIRKLE, DL ;
BAZAN, NG .
JOURNAL OF NEUROCHEMISTRY, 1987, 48 (06) :1768-1778
[9]   PLATELET-ACTIVATING-FACTOR (PAF) RECEPTOR IN RAT-BRAIN - PAF MOBILIZES INTRACELLULAR CA2+ IN HIPPOCAMPAL-NEURONS [J].
BITO, H ;
NAKAMURA, M ;
HONDA, Z ;
IZUMI, T ;
IWATSUBO, T ;
SEYAMA, Y ;
OGURA, A ;
KUDO, Y ;
SHIMIZU, T .
NEURON, 1992, 9 (02) :285-294
[10]  
BRAQUET P, 1987, PHARMACOL REV, V39, P97