SYNTHESIS OF CHAETOMELLIC ACID-A - A POTENT INHIBITOR OF RAS FARNESYL-PROTEIN TRANSFERASE

被引：40

作者：

SINGH, SB

机构：

[1] Merck Research Laboratories P. O., Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 41期

关键词：

D O I：

10.1016/0040-4039(93)88094-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chaetomellic adds are alkyl dicarboxylic acids, isolated from Chaetomella acutiseta and are potent and highly specific farnesyl-pyrophosphate (FPP) mimic inhibitors of Ras farnesyl-protein transferase. The first efficient and biogenetic type total synthesis of chaetomellic acid A has been described herein.

引用

页码：6521 / 6524

页数：4

共 9 条

[1] RAS GENES [J].