IMPAIRMENT OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION IN THE BRAIN OF AGED MICE

被引：76
作者：
FERRANDIZ, ML
MARTINEZ, M
DEJUAN, E
DIEZ, A
BUSTOS, G
MIQUEL, J
机构：
[1] UNIV ALICANTE, FAC MED, DEPT FARMACOL & TERAPEUT, E-03080 ALICANTE, SPAIN
[2] UNIV ALICANTE, FAC MED, INST NEUROCIENCIAS, E-03080 ALICANTE, SPAIN
[3] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46010 VALENCIA, SPAIN
来源：
BRAIN RESEARCH | 1994年 / 644卷 / 02期
关键词：
OXIDATIVE PHOSPHORYLATION; RESPIRATORY COMPLEX; MITOCHONDRION; BRAIN; AGING;
D O I：
10.1016/0006-8993(94)91699-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.
引用
收藏
页码：335 / 338
页数：4
相关论文
共 43 条
[1]   EFFECTS OF AGING ON RESPIRATION, ATP LEVELS AND CALCIUM-TRANSPORT IN RAT-LIVER MITOCHONDRIA - RESPONSE TO THEOPHYLLINE [J].
ALEMANY, J ;
DELACRUZ, MJ ;
RONCERO, I .
EXPERIMENTAL GERONTOLOGY, 1988, 23 (01) :25-34
[2]   THE MITOCHONDRIAL ELECTRON-TRANSFER ALTERATION AS A FACTOR INVOLVED IN THE BRAIN AGING [J].
BENZI, G ;
PASTORIS, O ;
MARZATICO, F ;
VILLA, RF ;
DAGANI, F ;
CURTI, D .
NEUROBIOLOGY OF AGING, 1992, 13 (03) :361-368
[3]   AGE-DEPENDENT IMPAIRMENT OF MITOCHONDRIAL-FUNCTION IN PRIMATE BRAIN [J].
BOWLING, AC ;
MUTISYA, EM ;
WALKER, LC ;
PRICE, DL ;
CORK, LC ;
BEAL, MF .
JOURNAL OF NEUROCHEMISTRY, 1993, 60 (05) :1964-1967
[4]   RESPIRATORY-CHAIN FAILURE IN ADULT MUSCLE-FIBERS - RELATIONSHIP WITH AGING AND POSSIBLE IMPLICATIONS FOR THE NEURONAL POOL [J].
BYRNE, E ;
DENNETT, X .
MUTATION RESEARCH, 1992, 275 (3-6) :125-131
[5]  
CAPOZZA G, 1993, B MOL BIOL MED, V18, P107
[6]   REPLICATION OF ANIMAL MITOCHONDRIAL-DNA [J].
CLAYTON, DA .
CELL, 1982, 28 (04) :693-705
[7]   ANALYSES OF MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION AND MITOCHONDRIAL-DNA DELETION IN HUMAN SKELETAL-MUSCLE - EFFECT OF AGING [J].
COOPER, JM ;
MANN, VM ;
SCHAPIRA, AHV .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1992, 113 (01) :91-98
[8]   AGE-RELATED MODIFICATIONS OF CYTOCHROME-C-OXIDASE ACTIVITY IN DISCRETE BRAIN-REGIONS [J].
CURTI, D ;
GIANGARE, MC ;
REDOLFI, ME ;
FUGACCIA, I ;
BENZI, G .
MECHANISMS OF AGEING AND DEVELOPMENT, 1990, 55 (02) :171-180
[9]  
Di Monte D. A., 1992, Society for Neuroscience Abstracts, V18, P1488
[10]   IS CELL AGING CAUSED BY RESPIRATION-DEPENDENT INJURY TO THE MITOCHONDRIAL GENOME [J].
FLEMING, JE ;
MIQUEL, J ;
COTTRELL, SF ;
YENGOYAN, LS ;
ECONOMOS, AC .
GERONTOLOGY, 1982, 28 (01) :44-53
12345