Effects of a filled fluoride-releasing enamel sealant versus fluoride varnish on the prevention of enamel demineralization under simulated oral conditions

Background: The development of white spot lesions is a common complication of orthodontic treatment. The use of a patient-independent method to control white spot lesions is desirable. This randomized, controlled, in vitro study was conducted to compare the effect of the use of a filled, fluoride-releasing, light-cured enamel sealant (Pro-Seal) versus fluoride varnish on the prevention of demineralization of intact enamel surface. Methods: Forty sound human premolar teeth were treated with either fluoride varnish or Pro-Seal sealant. Twenty sound human premolar teeth were used as controls. Specimens were subjected to thermocycling and brushing challenge protocols equivalent to 6 months and 1 year in oral environment. The teeth were then subjected to acid challenge. Prepared sections were examined under polarized light microscopy, and the depth of enamel demineralization was measured. Results: The fluoride varnish group showed significantly less lesion depth compared with the control group. The Pro-Seal group showed significantly less lesion depth compared with both the fluoride varnish group and the control group. Significantly deeper lesions were observed in specimens subjected to challenges equivalent to 1 year of oral environment compared with those subjected to challenges equivalent to 6 months of oral environment in the fluoride varnish group only. Conclusion: Application of either fluoride varnish or filled, fluoride-releasing, light-cured enamel sealant (Pro-Seal) was found to be efficacious in the prevention of enamel demineralization. (C) 2013 World Federation of Orthodontists.