ALPHA-2-ADRENOCEPTOR SENSITIVITY IN EARLY ALCOHOL-WITHDRAWAL

被引：23
作者：
BALLDIN, J
BERGGREN, U
ENGEL, J
LINDSTEDT, G
SUNDKLER, A
WALINDER, J
机构：
[1] GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN
[2] GOTHENBURG UNIV, DEPT PHARMACOL, S-41124 GOTHENBURG, SWEDEN
[3] GOTHENBURG UNIV, DEPT CLIN CHEM, S-41124 GOTHENBURG, SWEDEN
[4] LINKOPING UNIV, DEPT PSYCHIAT, S-58183 LINKOPING, SWEDEN
来源：
BIOLOGICAL PSYCHIATRY | 1992年 / 31卷 / 07期
关键词：
D O I：
10.1016/0006-3223(92)90281-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Growth hormone (GH), blood pressure, and pulse rate responses to clonidine (100-mu-g IV) were studied three times during the first week of alcohol withdrawal in 19 alcohol-dependent patients. Fifteen healthy men were used as controls. The results suggest reduced sensitivity of the alpha-2-adrenoceptors involved in GH secretion for at least 1 week after the end of alcohol intake. In contrast, very short-lasting subsensitivity was found in the alpha-2-adrenoceptors regulating blood pressure.
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页码：712 / 719
页数：8
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