LINKAGE MAP OF HUMAN CHROMOSOME-9 MICROSATELLITE POLYMORPHISMS

被引:63
作者
WILKIE, PJ
KRIZMAN, DB
WEBER, JL
机构
[1] MARSHFIELD MED RES FDN,1000 N OAK AVE,MARSHFIELD,WI 54449
[2] BAYLOR COLL MED,INST MOLEC GENET,HOUSTON,TX 77030
关键词
D O I
10.1016/0888-7543(92)90456-3
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Ten microsatellite markers composed of polymorphic (CA)n or (AAAT)n repeats were mapped to chromosome 9. PIC values for these markers ranged from 0.46 to 0.82. The marker at the D9S54 locus was localized to 9pter-p22 by means of a somatic cell hybrid; another marker at D9S103 was similarly localized to 9q34-qter. Two-point lod scores and individual meiotic recombination events were used to position the 10 markers relative to each other. The best order resulting from these analyses was D9S54-D9S104-[D9S52-D9S43-D9S50]-D9S53-[D9S106-D9S105]-D9S51-D9S103, with order of the loci within brackets uncertain. Two-point linkage analysis was also used to approximate the positions of the microsatellite markers relative to those of 33 markers contained in the public CEPH database (v.3) and to one other available microsatellite marker at the D9S15 locus. © 1992.
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页码:607 / 609
页数:3
相关论文
共 6 条
[1]  
MOHANDAS T, 1979, AM J HUM GENET, V31, P586
[2]   REPORT OF THE COMMITTEE ON THE GENETIC CONSTITUTION OF CHROMOSOME-9 AND CHROMOSOME-10 [J].
SMITH, M ;
SIMPSON, NE .
CYTOGENETICS AND CELL GENETICS, 1989, 51 (1-4) :202-225
[3]  
WALLIS J, 1990, HUM GENET, V85, P98
[4]   MAPPING OF HUMAN CHROMOSOME-5 MICROSATELLITE DNA POLYMORPHISMS [J].
WEBER, JL ;
POLYMEROPOULOS, MH ;
MAY, PE ;
KWITEK, AE ;
XIAO, H ;
MCPHERSON, JD ;
WASMUTH, JJ .
GENOMICS, 1991, 11 (03) :695-700
[5]  
WEBER JL, 1990, GENOME ANAL, V1, P159
[6]  
WEBER JL, 1990, NUCLEIC ACIDS RES, V18, P2203