AS DIENOGEST EFFECTIVELY SUPPRESSES ENDOMETRIOSIS, COULD IT ALSO REDUCE ENDOMETRIOSIS-ASSOCIATED OVARIAN CANCERS? A FURTHER MOTIVATION FOR LONG-TERM MEDICAL TREATMENT

被引：0

作者：

Del Pup, L. ^{[1
]}

Berretta, M. ^{[2
]}

机构：

[1] Natl Canc Inst, Gynecol Oncol, Aviano, PN, Italy

[2] Natl Canc Inst, Dept Med Oncol, Aviano, PN, Italy

来源：

WORLD CANCER RESEARCH JOURNAL | 2015年 / 2卷 / 02期

关键词：

Endometriosis; Dienogest; Ovarian cancer; Endometriotic cancer; Clear cells cancer; Ovulation inhibition; Progestogens; Inflammation; Apoptosis; Angiogenesis;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endometriosis increases the risk of endometriosis-associated ovarian cancer (EAOC). Although the issue is still controversial, the malignant transformation of endometriotic lesions seems more plausible than a mere risk factor sharing between endometriosis and ovarian cancer. As a consequence, an effective endometriosis suppressive medical treatment, like dienogest, could reduce at least some subtypes of estrogen sensitive ovarian cancer, like the endometrioid one. Endometriosis medical treatment aim is to control pain and to reduce surgery. The potential and still speculative ovarian cancer preventive effect could be a further suggestion to increase compliance to a long lasting treatment, while adequate clinical trials are necessary to confirm this hypothesis.

引用

页数：6