A model for hydride transfer in thymidylate synthase based on unnatural amino acid mutagenesis

被引：19
|
作者：
Barrett, JE [1 ]
Lucero, CM [1 ]
Schultz, PG [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 34期
关键词：
D O I：
10.1021/ja991040+
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：7965 / 7966
页数：2
相关论文
共 50 条
  • [1] Hydride transfer versus hydrogen radical transfer in thymidylate synthase
    Hong, B
    Haddad, M
    Maley, F
    Jensen, JH
    Kohen, A
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) : 5636 - 5637
  • [2] Unnatural amino acid mutagenesis-based enzyme engineering
    Ravikumar, Yuvaraj
    Nadarajan, Saravanan Prabhu
    Yoo, Tae Hyeon
    Lee, Chong-soon
    Yun, Hyungdon
    TRENDS IN BIOTECHNOLOGY, 2015, 33 (08) : 462 - 470
  • [3] In vivo photocrosslinking with unnatural amino acid mutagenesis
    Chin, JW
    Schultz, PG
    CHEMBIOCHEM, 2002, 3 (11) : 1135 - 1137
  • [4] Unnatural Amino Acid Mutagenesis of Fluorescent Proteins
    Wang, Feng
    Niu, Wei
    Guo, Jiantao
    Schultz, Peter G.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (40) : 10132 - 10135
  • [5] A General Method for Scanning Unnatural Amino Acid Mutagenesis
    Daggett, Kelly A.
    Layer, Mark
    Cropp, T. Ashton
    ACS CHEMICAL BIOLOGY, 2009, 4 (02) : 109 - 113
  • [6] Caging proteins through unnatural amino acid mutagenesis
    Petersson, EJ
    Brandt, GS
    Zacharias, NM
    Dougherty, DA
    Lester, HA
    BIOPHOTONICS, PT A, 2003, 360 : 258 - 273
  • [7] Unnatural amino acid mutagenesis of green fluorescent protein
    Wang, L
    Xie, JM
    Deniz, AA
    Schultz, PG
    JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (01): : 174 - 176
  • [8] Unnatural amino acid mutagenesis in mapping ion channel function
    Beene, DL
    Dougherty, DA
    Lester, HA
    CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (03) : 264 - 270
  • [9] An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli
    Young, Travis S.
    Ahmad, Insha
    Yin, Jun A.
    Schultz, Peter G.
    JOURNAL OF MOLECULAR BIOLOGY, 2010, 395 (02) : 361 - 374
  • [10] A Remote Mutation Affects the Hydride Transfer by Disrupting Concerted Protein Motions in Thymidylate Synthase
    Wang, Zhen
    Abeysinghe, Thelma
    Finer-Moore, Janet S.
    Stroud, Robert M.
    Kohen, Amnon
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (42) : 17722 - 17730
12345