Personalized cancer medicine: present status and future perspectives

被引:0
作者
Heo, Dae Seog [1 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
来源
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION | 2015年 / 58卷 / 11期
关键词
Cancer; Precision medicine; Next generation sequencing; Oncogenes; Targeted agents;
D O I
10.5124/jkma.2015.58.11.1021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most cancers have oncogenes and tumor suppressor genes. First successful drug targeting a oncogene is imatinib. It was very effective for chronic myelogenous leukemia as well as gastrointestinal stromal tumors. Many other targeted agents showed good response: trastuzumab for breast cancer, epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer, etc. Tests for EGFR and ALK gene mutation are routinely recommended for adenocarcinoma of lung cancer for selection of anticancer treatment. In addition, large-scale genomic data generation (next generation sequencing) is feasible in a clinical setting and gives us high hope for personalized cancer medicine. However, there are many hurdles to overcome. Driver genes must be distinguished from the passenger genes that are present in tumor DNA. In case of targeted cancer therapy, emergence of drug resistance due to tumor cell heterogeneity and clonal evolution is difficult to manage. Genetic testing for cancer risk showed some success in preventing familial breast or ovarian cancers, but it cannot be generalized in other tumors. Application of genetic information in cancer medicine showed promise but evidence-based approach is needed in clinical practice.
引用
收藏
页码:1021 / 1026
页数:6
相关论文
共 50 条
  • [31] Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease
    Esplin, Edward D.
    Oei, Ling
    Snyder, Michael P.
    PHARMACOGENOMICS, 2014, 15 (14) : 1771 - 1790
  • [32] The application of immunonutrition in patients with cancer: current status and future perspectives
    Yudi Liu
    Fangqi Li
    Jifan Hu
    Jiuwei Cui
    Holistic Integrative Oncology, 3 (1):
  • [33] Nutrition, Cancer and Personalized Medicine
    Ali Flores-Perez, Jose
    de la Rosa Oliva, Fabiola
    Argenes, Yacab
    Meneses-Garcia, Abelardo
    TRANSLATIONAL RESEARCH AND ONCO-OMICS APPLICATIONS IN THE ERA OF CANCER PERSONAL GENOMICS, 2019, 1168 : 157 - 168
  • [34] Limits to Personalized Cancer Medicine
    Tannock, Ian F.
    Hickman, John A.
    NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (13) : 1289 - 1294
  • [35] Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives
    Piras, Daniele
    Xia, Wenfeng
    Steenbergen, Wiendelt
    van Leeuwen, Ton. G.
    Manohar, Srirang
    IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2010, 16 (04) : 730 - 739
  • [36] The future of precision medicine: towards a more predictive personalized medicine
    Elemento, Olivier
    EMERGING TOPICS IN LIFE SCIENCES, 2020, 4 (02) : 175 - 177
  • [37] Recent Developments and Future Perspectives of Personalized Oncology
    Gruellich, Carsten
    von Kalle, Christof
    ONKOLOGIE, 2012, 35 : 4 - 7
  • [38] The growing role of precision and personalized medicine for cancer treatment
    Krzyszczyk, Paulina
    Acevedo, Alison
    Davidoff, Erika J.
    Timmins, Lauren M.
    Marrero-Berrios, Ileana
    Patel, Misaal
    White, Corina
    Lowe, Christopher
    Sherba, Joseph J.
    Hartmanshenn, Clara
    O'Neill, Kate M.
    Balter, Max L.
    Fritz, Zachary R.
    Androulakis, Ioannis P.
    Schloss, Rene S.
    Yarmush, Martin L.
    TECHNOLOGY, 2018, 6 (3-4): : 79 - 100
  • [39] microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers
    Saumet, Anne
    Lecellier, Charles-Henri
    MICRORNA: MEDICAL EVIDENCE: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE, 2015, 888 : 5 - 15
  • [40] VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review)
    Taurone, Samanta
    Galli, Filippo
    Signore, Alberto
    Agostinelli, Enzo
    Dierckx, Rudi A. J. O.
    Minni, Antonio
    Pucci, Marcella
    Artico, Marco
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 49 (02) : 437 - 447