MODELING OF TRANSMEMBRANE 7 HELIX BUNDLES

被引：95
作者：
CRONET, P
SANDER, C
VRIEND, G
机构：
[1] EMBL
来源：
PROTEIN ENGINEERING | 1993年 / 6卷 / 01期
关键词：
BETA-ADRENOCEPTOR; BACTERIORHODOPSIN; PROTEIN STRUCTURE PREDICTION; RECEPTOR; SEQUENCE STRUCTURE ALIGNMENT;
D O I：
10.1093/protein/6.1.59
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transmembrane seven helix bundles form a large family of membrane inserted receptors and are responsible for a wide range of biological functions. Experimental data suggest that their overall structure is similar to bacteriorhodopsin. We describe here a new approach for the modeling of transmembrane seven helix bundles based on statistically derived environmental preference parameters combined with experimentally determined features of the receptors. The method was used to create a model for the human beta2-adrenoreceptor. This model is physically plausible, is in reasonable agreement with experimental data and may be helpful in planning new receptor engineering experiments.
引用
收藏
页码：59 / 64
页数：6
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